Products for Research Use Only
RegisterLogin

PCSK5 rabbit pAb

CAT: 0855-ES14196-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES14196-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B) . [provided by RefSeq, May 2014]
Description
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014],
UniProt
Q92824
Swiss Prot
Q92824
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human PCSK5 AA range: 1507-1557
Target
PCSK5
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
[Isoform PC6A]: Secreted. Secreted through the regulated secretory pathway. .; [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein. Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. .
Gene ID (Human)
5125

Related Products

CatalogName
ES14195-01PCSK6 rabbit pAb
ES20358-01PCSK9 rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb
ES20829-01ATG4a Rabbit rabbit pAb
ES20658-01NM23A Rabbit rabbit pAb
ES20826-01ATG5 Rabbit rabbit pAb

Alternative Products

CatalogName
E45R25840N-50PCSK5 Rabbit pAb
E10G09960PCSK5 Rabbit Polyclonal Antibody
GB114694Anti-PCSK5 Rabbit pAb
GTR18402464-01PCSK5 rabbit pAb Antibody
APR25840N-01PCSK5 Rabbit pAb (APR25840N)
TA366070PC6 (PCSK5) Rabbit Polyclonal Antibody
GTR18378306PCSK5 Rabbit Polyclonal Antibody (HRP)
GTR18378308PCSK5 Rabbit Polyclonal Antibody (Biotin)
WP17066-01U-Blot® PCSK5 rabbit pAb
PA14077-01Rabbit Anti-Human PCSK5 pAb

Popular Products