Sheep anti-Cytochrome C

Sheep anti-Cytochrome C

• Background: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain._x000B_Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases._x000B_Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
• CAS Number: 9007-83-4
• UniProt: P00011 (Canine), P00008 (Rabbit), P62898 (Rat), P99999 (Human)
• Host: Sheep
• Species Reactivity: Human, Rat, Rabbit, Dog
• Clone: Polyclonal
• Type: Primary Antibodies
• Applications: WB, IP, IHC
• Purification Method: Whole Antiserum, no purification
• Assay Principle: Western Blot|Immunoprecipitation|Immunohistochemistry
• Form: Whole sheep antiserum, no carrier or preservative added
• Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles