Sheep anti-Cytochrome C

• Background:

  Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain._x000B_Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases._x000B_Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

• UniProt:

  P00011 (Canine), P00008 (Rabbit), P62898 (Rat), P99999 (Human)

• Host:

  Sheep

• Species Reactivity:

  Human, Rat, Rabbit, Dog

• Clone:

  Polyclonal

• Type:

  Primary Antibodies

• Applications:

  WB, IP, IHC

• Purification Method:

  Whole Antiserum, no purification

• Assay Principle:

  Western Blot|Immunoprecipitation|Immunohistochemistry

• Form:

  Whole sheep antiserum, no carrier or preservative added

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• CAS Number:

  9007-83-4