Sheep anti EBNA 3B

Sheep anti EBNA 3B

• Background: EBNA-3B is one of only 10 viral proteins expressed in EBV-transformed B lymphoblasts cultured in vitro, through the expression of EBNA 3B is not required for EBV-mediated transformation in vitro. This 165kDa nuclear protein functions as a transcription factor.
• Synonyms: EBNA3B, Epstein-Barr Virus nuclear Antigen 4
• UniProt: P03203 (EBV/HHV4)
• Host: Sheep
• Species Reactivity: Epstein-Barr Virus
• Isotype: IgG
• Conjugation: Unconjugated
• Type: Polyclonal Antibody
• Source: Sheep were immunized with recombinant EBNA-3B protein
• Applications: ELISA, ICC, IHC (paraffin), Dot blot, WB
• Field of Research: Infectious Agents and Disease, Microbiology
• Purification Method: Ammonium sulfate precipitation
• Assay Principle: Western blotting at 1-5 µg/mL
• Stability: See expiration date on vial
• Concentration: See vial for Concentration
• Form: Provided as solution in phosphate buffered saline with 0,08% sodium azide
• Precautions: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
• References & Citations: 1. Anderton, E., et al, 'Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma' Oncogene 2007, 27, , 421-433_x000D_ 2. O'Nions, J., et al, 'Epstein–Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2' Oncogene 2003, 22, , 7181-7191_x000D_ 3. Jiménez-Ramírez, C., et al, 'Epstein-Barr Virus EBNA-3C Is Targeted to and Regulates Expression from the Bidirectional LMP-1/2B Promoter' Journal of Virology 2006, 80, , 11200-11208_x000D_ 4. Yuan, J., et al, 'Virus and Cell RNAs Expressed during Epstein-Barr Virus Replication' Journal of Virology 2006, 80, , 2548-2565_x000D_ 5. Hong, G.K., et al, 'Epstein-Barr Virus Lytic Infection Contributes to Lymphoproliferative Disease in a SCID Mouse Model' Journal of Virology 2005, 79, , 13993-14003_x000D_ 6. Rosendorff, A., et al, 'EBNA3C Coactivation with EBNA2 Requires a SUMO Homology Domain' Journal of Virology 2004, 78, , 367-377_x000D_ 7. Maruo, S., et al, 'Epstein-Barr Virus Nuclear Protein EBNA3A Is Critical for Maintaining Lymphoblastoid Cell Line Growth' Journal of Virology 2003, 77, , 10437-10447_x000D_ 8. Gordadze, A.V., et al, 'Notch1IC Partially Replaces EBNA2 Function in B Cells Immortalized by Epstein-Barr Virus' Journal of Virology 2001, 75, , 5899-5912
• Shipping Conditions: Ambient Temperature
• Storage Conditions: Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
• Functional Analysis: WB