Sheep anti Chicken Alk2

• Background:

  Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor- (TGF- ). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. Additionally, it induces the Tlx2 promoter in the absense of BMP7.

• Synonyms:

  Activin Receptor-Like Kinase 2

• UniProt:

  Q90ZK6

• Host:

  Sheep

• Species Reactivity:

  Chicken

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Field of Research:

  Signal Transduction

• Purification Method:

  Ammonium Sulfate Precipitation

• Assay Principle:

  Antibody can be used for Western blotting (5-10 µg/mL), immunoprecipitation (5 µg/mg of protein lysate and immunohistochemistry on paraffin embedded tissue sections (5-10 µg/mL). Optimal concentration should be evaluated by serial dilutions.

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided as solution in phosphate buffered saline with 0,08% sodium azide

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• References & Citations:

  1. Lai, Y.T., et al. 'Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation.' Dev. Biol. 2000, 222, 1-11. 2. Gu, Z., et al. 'The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo.' Development 1999, 126, 2551-2561. 3. Macias-Silva, M., et al. 'Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.' J. Biol. Chem. 1998, 273, 25628-25636

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  WB

• CAS Number:

  9007-83-4