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PHA-767491 (hydrochloride)

CAT: 0804-HY-13461A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13461A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively.
CAS Number
942425-68-5
Product Name Alternative
CAY-10572 hydrochloride
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PHA-767491-hydrochloride.html
Purity
99.49
Solubility
DMSO : 17.33 mg/mL (ultrasonic; warming) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C1C2=C(NC(C3=CC=NC=C3)=C2)CCN1.[H]Cl
Molecular Formula
C12H12ClN3O
Molecular Weight
249.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9 (11) :e113300.|[2]Li W, et al. Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. Curr Cancer Drug Targets. 2015;15 (3) :196-204.|[3]Erbayraktar Z, et al. Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness. Cancer Cell Int. 2016 Nov 18;16:88.|[4]Montagnoli A, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4 (6) :357-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK5; CDK9
Citation 01
Autophagy. 2022 Aug;18 (8) :1879-1897.|Sci Rep. 2021 Mar 8;11 (1) :5374.|Acta Pharmacol Sin. 2022 Apr;43 (4) :1033-1045.|Nat Commun. 2024 Dec 5;15 (1) :10594.

Chemical Information

PHA-767491 hydrochloride
CAS Number942425-68-5
PubChem CID11715766
IUPAC Name2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one;hydrochloride
Molecular FormulaC12H12ClN3O
Molecular Weight249.69
Topological Polar Surface Area57.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity275
SMILES
C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3.Cl
InChI
InChI=1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H
InChIKey
IMVNFURYBZMFDZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PHA-767491 hydrochloride
CAS: 942425-68-5
CID: 11715766
Formula: C12H12ClN3O
MW: 249.69
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight249.69
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass249.0668897
Monoisotopic Mass249.0668897
Topological Polar Surface Area57.8 Ų
Heavy Atom Count17
Formal Charge0
Complexity275
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
256228-01PHA 767491 hydrochloride
BUP15519-01PHA-767491 hydrochloride
A21395-25PHA-767491 hydrochloride 25mg
A21395-5PHA-767491 hydrochloride 5mg
A21395-200PHA-767491 hydrochloride 200mg
A21395-100PHA-767491 hydrochloride 100mg
A21395-10PHA-767491 hydrochloride 10mg
A21395-50PHA-767491 hydrochloride 50mg
A21395-10mM-DPHA-767491 hydrochloride 10mM * 1mL in DMSO
471087PHA 543613 hydrochloride

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