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PHA-543613 (hydrochloride)

CAT: 0804-HY-105670ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-105670ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHA-543613 hydrochloride is an oral or active α7 nAChR agonist with brain permeability, For α3β4, α1β1γδ, α4β2 and 5-HT3 receptors selective. PHA-543613 hydrochloride affects sensory gating and memory in an in vivo model of schizophrenia[1][1].
CAS Number
1586767-92-1
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pha-543613-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(OC=C2)C=N1)N[C@H]3CN4CCC3CC4.[H]Cl
Molecular Formula
C15H18ClN3O2
Molecular Weight
307.78
References & Citations
[1]Faghih R, et al. Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. J Med Chem. 2008 Feb 28;51 (4) :701-12.|[2]Wishka DG, et al. Discovery of N-[ (3R) -1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13;49 (14) :4425-36.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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