PHA-680626

• Description :

  PHA-680626 is an effective inhibitor of the interaction between Aurora-A and N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib (HY-15463) -resistant chronic myeloid leukemia cell lines and primary CD34+ cells[1].

• CAS Number :

  [398493-74-8]

• UNSPSC :

  12352005

• Target :

  Apoptosis; Aurora Kinase; Bcr-Abl; c-Myc; Histone Methyltransferase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pha-680626.html

• Smiles :

  O=C(NC1=NNC2=C1CN(C(CC3=CC=CS3)=O)C2)C4=CC=C(N5CCN(C)CC5)C=C4

• Molecular Formula :

  C23H26N6O2S

• Molecular Weight :

  450.56

• References & Citations :

  [1]Boi D, et al. PHA-680626 Is an Effective Inhibitor of the Interaction between Aurora-A and N-Myc. Int J Mol Sci. 2021 Dec 4;22 (23) :13122. |[2]Gontarewicz A, et al. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. Leuk Res. 2008 Dec;32 (12) :1857-65.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported