WHN-88

CAT: 0804-HY-164547Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-164547Size:1 Each
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Description
WHN-88 is a Porcupine (PORCN) inhibitor. WHN-88 can eliminate the palmitoylation of Wnt ligands, preventing their secretion and subsequent Wnt/β-catenin signaling. WHN-88 can inhibit cancer cell stemness and suppress the occurrence and development of breast tumors in MMTV-Wnt1 transgenic mice[1].
CAS Number
[2490686-86-5]
UNSPSC
12352005
Target
Porcupine; Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/whn-88.html
Smiles
O=C(CN1C=C(I)C(C(I)=C1)=O)NC2=NC=C(C3=CC=CC=C3)C=C2
Molecular Formula
C18H13I2N3O2
Molecular Weight
557.12
References & Citations
[1]Yang Q, et al. Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers. Eur J Pharmacol. 2023 Apr 15;945:175628.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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