WHN-88

• Description:

  WHN-88 is a Porcupine (PORCN) inhibitor. WHN-88 can eliminate the palmitoylation of Wnt ligands, preventing their secretion and subsequent Wnt/β-catenin signaling. WHN-88 can inhibit cancer cell stemness and suppress the occurrence and development of breast tumors in MMTV-Wnt1 transgenic mice[1].

• UNSPSC:

  12352005

• Target:

  Porcupine; Wnt; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/whn-88.html

• Smiles:

  O=C(CN1C=C(I)C(C(I)=C1)=O)NC2=NC=C(C3=CC=CC=C3)C=C2

• Molecular Formula:

  C18H13I2N3O2

• Molecular Weight:

  557.12

• References & Citations:

  [1]Yang Q, et al. Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers. Eur J Pharmacol. 2023 Apr 15;945:175628.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2490686-86-5]