AChE-IN-88

• Description:

  AChE-IN-88 (Compound 26) is a novel pyridazine derivative. AChE-IN-88 is an orally active multi-target ligand for Alzheimer's disease (AD) that inhibits both acetylcholinesterase (AChE) and amyloid β protein (Aβ) aggregation (pIC50: 7.16) [1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Cholinesterase (ChE)

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  FC1=CC (CN (CC) CCCCCCN2N=C (C3=CC (NC (C) =O) =CC=C3O) C=CC2=O) =CC=C1

• Molecular Formula:

  C27H33FN4O3

• Molecular Weight:

  480.57

• References & Citations:

  [1]Aloui M, et al. In silico design of novel pyridazine derivatives as balanced multifunctional agents against Alzheimer's disease. Sci Rep. 2025 May 7;15 (1) :15910.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE

• CAS Number:

  2758789-03-4