GB-88

• Description :

  GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 μM[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Protease Activated Receptor (PAR)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/gb-88.html

• Purity :

  99.05

• Solubility :

  DMSO : 31.25 mg/mL (ultrasonic)

• Smiles :

  O=C([C@H]([C@@H](C)CC)NC([C@H](CC1CCCCC1)NC(C2=CC=NO2)=O)=O)N3CCC4(C=CC5=C4C=CC=C5)CC3

• Molecular Formula :

  C32H42N4O4

• Molecular Weight :

  546.70

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Suen JY, et al. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) . Br J Pharmacol. 2012 Mar;165 (5) :1413-23.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PAR2

• CAS Number :

  [1416435-96-5]