Phospho-Nucleophosmin (S125) Recombinant Rabbit Monoclonal Antibody [JE51-14]

Phospho-Nucleophosmin (S125) Recombinant Rabbit Monoclonal Antibody [JE51-14]

• Description: Nucleophosmin (NPM), also known as nucleolar phosphoprotein B23 or numatrin, is a protein that in humans is encoded by the NPM1 gene. NPM1 is associated with nucleolar ribonucleoprotein structures and binds single-stranded and double-stranded nucleic acids, but it binds preferentially G-quadruplex forming nucleic acids. It is involved in the biogenesis of ribosomes and may assist small basic proteins in their transport to the nucleolus. Its regulation through SUMOylation (by SENP3 and SENP5) is another facet of the protein's regulation and cellular functions. It is located in the nucleolus, but it can be translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. The protein was identified as a phosphoprotein. However, later other post-translational modifications for NPM1 were identified including acetylation and SUMOylation.
• Product Name Alternative: B23 antibody MGC104254 antibody NO38 antibody NPM antibody NPM_HUMAN antibody NPM1 antibody Nucleolar phosphoprotein B23 antibody Nucleolar protein NO38 antibody Nucleophosmin (nucleolar phosphoprotein B23 numatrin) antibody Nucleophosmin antibody nucleophosmin nucleoplasmin family member 1 antibody Nucleophosmin/nucleoplasmin family member 1 antibody Numatrin antibody OTTHUMP00000161024 antibody OTTHUMP00000161025 antibody OTTHUMP00000223397 antibody OTTHUMP00000223398 antibody
• Abbreviation: NPM1, NPM
• CAS Number: 9000-83-3
• Swiss Prot: P06748 Human, Q61937 Mouse, P13084 Rat
• Cellular Locus: Nucleus, nucleolus, nucleoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within
• Isotype: IgG
• Clone: JE51-14
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell, FC
• Positive Control: HeLa cell lysate, NIH/3T3 cell lysate, F9 cell lysate, RAW264.7 cell lysate, L6 cell lysate, PC-12 cell lysate, human kidney tissue, mouse kidney tissue, rat kidney tissue, HeLa, NIH/3T3.
• Concentration: 1 mg/mL
• Dilution: WB: 1:5,000 ;IHC-P: 1:10,000 ;IF-Cell: 1:500 ;FC: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 33 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes