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1,10-Decanediol-d20

CAT: 0804-HY-W016773SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W016773SSize:1 mg
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Description
1,10-Decanediol-d20 is the deuterium labeled 1,10-Decanediol[1]. 1,10-Decanediol is a diol compound that can react with α-ketoglutarate (aKG) to generate polymeric microparticles (termed paKG MPs) for the sustained release of aKG, thereby promoting immunosuppressive regulation. Additionally, paKG MPs can bind to dendritic cells (DCs), reducing their glycolysis and mitochondrial respiration in vitro. These metabolic changes lead to the modulation of MHC-II and CD86 expression in DCs and alter the frequency of regulatory T cells (Tregs) as well as T-helper type 1/2/17 cells in vitro. 1,10-Decanediol can be used in research within the field of immunometabolism. can be used as a surfactant/stabilizer in the synthesis of nanomaterials[1][2].
CAS Number
347841-78-5
UNSPSC
12352211
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])O
Molecular Formula
C10H2D20O2
Molecular Weight
194.40
References & Citations
[1]Mangal JL, et al. Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism. J Mater Chem B. 2020 Jun 24;8 (24) :5195-5203. |[2]Harris R A, et al. Molecular dynamics study on iron oxide nanoparticles stabilised with Sebacic Acid and 1, 10-Decanediol surfactants[J]. Journal of Molecular Structure, 2013, 1048: 18-26.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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