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Dipyridamole-d20

CAT: 0804-HY-B0312SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0312SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dipyridamole-d20 is the deuterium labeled Dipyridamole. Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells[1][2][3].
CAS Number
1189983-52-5
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
98.0
Solubility
H2O : < 0.1 mg/mL
Smiles
N(CCO)(CCO)C1=NC2=C(C(=N1)N3C(C(C(C(C3([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])N=C(N(CCO)CCO)N=C2N4C(C(C(C(C4([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H]
Molecular Formula
C24H20D20N8O4
Molecular Weight
524.75
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Klabunde, R.E., Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol, 1983. 93 (1-2) : p. 21-6.|[3]Best, L.C., et al., Mode of action of dipyridamole on human platelets. Thromb Res, 1979. 16 (3-4) : p. 367-79.|[4]Aktas, B., et al., Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies. Stroke, 2003. 34 (3) : p. 764-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

CatalogName
CS-O-03047Dipyridamole-d20
TRC-D492627-1MGDipyridamole-d20 (Major)
D3754-10CDipyridamole-d20 (2,2’,2’’,2’’’-[ (4,8-Di-1-piperidinyl-d20-pyrimido[5,4-d]pyrimidine-2,6-diyl) dinitrilo]tetrakis-ethanol, NSC-515776-d20, RA-8-d20, Anginal-d20, Cardoxin-d20, Cleridium-d20, Dipyridan-d20, Natyl-d20, Peridamol-d20, Persantine-d20)
MBS6089162-01Dipyridamole-d20 (2,2',2'',2'''-[ (4,8-Di-1-piperidinyl-d20-pyrimido[5,4-d]pyrimidine-2,6-diyl) dinitrilo]tetrakis-ethanol, NSC-515776-d20, RA-8-d20, Anginal-d20, Cardoxin-d20, Cleridium-d20, Dipyridan-d20, Natyl-d20, Peridamol-d20, Persantine-d20)
B1933-SDipyridamole

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