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1,10-Decanediol

CAT: 0804-HY-W016773-01Size: 100 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W016773-01Size:100 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1,10-Decanediol is a diol compound that can react with α-ketoglutarate (aKG) to generate polymeric microparticles (termed paKG MPs) for the sustained release of aKG, thereby promoting immunosuppressive regulation. Additionally, paKG MPs can bind to dendritic cells (DCs), reducing their glycolysis and mitochondrial respiration in vitro. These metabolic changes lead to the modulation of MHC-II and CD86 expression in DCs and alter the frequency of regulatory T cells (Tregs) as well as T-helper type 1/2/17 cells in vitro. 1,10-Decanediol can be used in research within the field of immunometabolism. can be used as a surfactant/stabilizer in the synthesis of nanomaterials[1][2].
CAS Number
112-47-0
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
MHC; Transmembrane Glycoprotein
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-10-decanediol.html
Purity
99.93
Smiles
OCCCCCCCCCCO
Molecular Formula
C10H22O2
Molecular Weight
174.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Mangal JL, et al. Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism. J Mater Chem B. 2020 Jun 24;8 (24) :5195-5203.|[2]Harris R A, et al. Molecular dynamics study on iron oxide nanoparticles stabilised with Sebacic Acid and 1, 10-Decanediol surfactants[J]. Journal of Molecular Structure, 2013, 1048: 18-26.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
Phase 1

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