L-2-Hydroxyglutaric acid
CAT:
804-HY-113039-02
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
L-2-Hydroxyglutaric acid
- CAS Number: 13095-48-2
- UNSPSC Description: L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].
- Target Antigen: Endogenous Metabolite; Histone Demethylase; Mitochondrial Metabolism
- Type: Natural Products
- Related Pathways: Epigenetics;Metabolic Enzyme/Protease
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/L-2-Hydroxyglutaric_acid.html
- Purity: 95.0
- Solubility: 10 mM in DMSO
- Smiles: O=C(O)[C@@H](O)CCC(O)=O
- Molecular Weight: 148.11
- References & Citations: [1]Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.|[2]da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24.
- Shipping Conditions: Blue Ice
- Storage Conditions: Solution, -20°C, 2 years
- Clinical Information: No Development Reported