L-2-Hydroxyglutaric acid

• CAS Number :

  13095-48-2

• Target :

  Histone Demethylase|||Endogenous Metabolite|||Mitochondrial Metabolism

• Related Pathways :

  Metabolism|||Chromatin/Epigenetic

• Bioactivity :

  L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH) . It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research.

• Smiles :

  [C@H](CCC(O)=O)(C(O)=O)O

• Molecular Formula :

  C5H8O5

• Molecular Weight :

  148.11

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C