L-2-Hydroxyglutaric acid (disodium)

L-2-Hydroxyglutaric acid (disodium)

• CAS Number: 63512-50-5
• UNSPSC Description: L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].
• Target Antigen: Endogenous Metabolite; Histone Demethylase; Mitochondrial Metabolism
• Type: Reference compound
• Related Pathways: Epigenetics;Metabolic Enzyme/Protease
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/l-2-hydroxyglutaric-acid-disodium.html
• Purity: 99.12
• Solubility: H2O : 83.33 mg/mL (ultrasonic)
• Smiles: O=C(O[Na])[C@@H](O)CCC(O[Na])=O
• Molecular Weight: 192.08
• References & Citations: [1]Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.|[2]da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported