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L-2-Hydroxyglutaric acid

CAT: 0804-HY-113039-01Size: 5 mg (67.52 mM x 0.5 mL in Ethanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-113039-01Size:5 mg (67.52 mM x 0.5 mL in Ethanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].
CAS Number
13095-48-2
Product Name Alternative
(S) -2-Hydroxyglutaric acid
UNSPSC
12352211
Hazard Statement
H302, H312, H332
Target
Endogenous Metabolite; Histone Demethylase; Mitochondrial Metabolism
Type
Natural Products
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/L-2-Hydroxyglutaric_acid.html
Concentration
67.52 mM * 1 mL in Ethanol
Purity
95.11
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@@H](O)CCC(O)=O
Molecular Formula
C5H8O5
Molecular Weight
148.11
Precautions
H302, H312, H332
References & Citations
[1]Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4 (11) :1290-8.|[2]da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21 (4) :217-24.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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