(4-NH2)-Exatecan-d5

(4-NH2)-Exatecan-d5

• UNSPSC Description: (4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan[1]. (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[2].
• Target Antigen: ADC Cytotoxin; Isotope-Labeled Compounds; Topoisomerase
• Type: Isotope-Labeled Compounds
• Related Pathways: Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Solubility: DMSO : 33.33 mg/mL (ultrasonic)
• Smiles: O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5N)=CC6=C1COC([C@]6(O)C([2H])([2H])C([2H])([2H])[2H])=O
• Molecular Weight: 408.46
• References & Citations: [1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported