Azido-PEG4-alcohol

• UNSPSC Description:

  Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG4-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/azido-peg4-alcohol.html

• Purity:

  98.64

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 80°C)|H2O : ≥ 100 mg/mL

• Smiles:

  [N-]=[N+]=NCCOCCOCCOCCO

• Molecular Weight:

  219.24

• References & Citations:

  [1]Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  86770-67-4