Azido-PEG4-THP

• Description :

  Azido-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• UNSPSC :

  12352005

• Target :

  PROTAC Linkers

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/azido-peg4-thp.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [N-]=[N+]=NCCOCCOCCOCCOC1OCCCC1

• Molecular Formula :

  C13H25N3O5

• Molecular Weight :

  303.35

• References & Citations :

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PEG Linkers

• CAS Number :

  [145927-74-8]