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Azido-PEG4-alcohol

CAT: 0804-HY-22340-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-22340-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Azido-PEG4-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
86770-67-4
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg4-alcohol.html
Purity
98.88
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : ≥ 100 mg/mL
Smiles
[N-]=[N+]=NCCOCCOCCOCCO
Molecular Formula
C8H17N3O4
Molecular Weight
219.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28 (1) :115228.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethanol
CAS Number86770-67-4
PubChem CID4614742
IUPAC Name2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol
Molecular FormulaC8H17N3O4
Molecular Weight219.24
XLogP0
Topological Polar Surface Area62.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Heavy Atom Count15
Formal Charge0
Complexity173
SMILES
C(COCCOCCOCCO)N=[N+]=[N-]
InChI
InChI=1S/C8H17N3O4/c9-11-10-1-3-13-5-7-15-8-6-14-4-2-12/h12H,1-8H2
InChIKey
MBQYGQMGPFNSAP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethanol
CAS: 86770-67-4
CID: 4614742
Formula: C8H17N3O4
MW: 219.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight219.24
XLogP30
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Exact Mass219.12190603
Monoisotopic Mass219.12190603
Topological Polar Surface Area62.3 Ų
Heavy Atom Count15
Formal Charge0
Complexity173
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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