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Azido-PEG4-propargyl

CAT: 0804-HY-132050Size: 1 EachDry Ice: NoHazardous: No
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Description
Azido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
CAS Number
1192590-91-2
UNSPSC
12352211
Hazard Statement
H301-H311-H331-H341
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg4-propargyl.html
Solubility
10 mM in DMSO
Smiles
C#CCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Formula
C11H19N3O4
Molecular Weight
257.29
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

Azido-PEG4-propargyl
CAS Number1192590-91-2
PubChem CID86672682
IUPAC Name3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]prop-1-yne
Molecular FormulaC11H19N3O4
Molecular Weight257.29
XLogP0.7
Topological Polar Surface Area51.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count13
Heavy Atom Count18
Formal Charge0
Complexity271
SMILES
C#CCOCCOCCOCCOCCN=[N+]=[N-]
InChI
InChI=1S/C11H19N3O4/c1-2-4-15-6-8-17-10-11-18-9-7-16-5-3-13-14-12/h1H,3-11H2
InChIKey
FDQQZUZMUONMHN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-PEG4-propargyl
CAS: 1192590-91-2
CID: 86672682
Formula: C11H19N3O4
MW: 257.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight257.29
XLogP30.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count13
Exact Mass257.13755610
Monoisotopic Mass257.13755610
Topological Polar Surface Area51.3 Ų
Heavy Atom Count18
Formal Charge0
Complexity271
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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