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Azido-PEG4-hydrazide

CAT: 0804-HY-140814-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140814-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Azido-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
2170240-96-5
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg4-hydrazide.html
Purity
99.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NN)CCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Formula
C11H23N5O5
Molecular Weight
305.33
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

Azido-PEG4-hydrazide
CAS Number2170240-96-5
PubChem CID131954358
IUPAC Name3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]propanehydrazide
Molecular FormulaC11H23N5O5
Molecular Weight305.33
XLogP-1
Topological Polar Surface Area106
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count15
Heavy Atom Count21
Formal Charge0
Complexity299
SMILES
C(COCCOCCOCCOCCN=[N+]=[N-])C(=O)NN
InChI
InChI=1S/C11H23N5O5/c12-15-11(17)1-3-18-5-7-20-9-10-21-8-6-19-4-2-14-16-13/h1-10,12H2,(H,15,17)
InChIKey
BUAWGAVOHIVJRC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azido-PEG4-hydrazide
CAS: 2170240-96-5
CID: 131954358
Formula: C11H23N5O5
MW: 305.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight305.33
XLogP3-1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count15
Exact Mass305.16991885
Monoisotopic Mass305.16991885
Topological Polar Surface Area106 Ų
Heavy Atom Count21
Formal Charge0
Complexity299
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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