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PCSK9-IN-27

CAT: 0804-HY-161435Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161435Size:1 Each
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Description
PCSK9-IN-27 (Compound 108) is a PCSK9 inhibitor (IC50: 3.4 nM) . PCSK9-IN-27 reduces LDLR degradation and increases LDL-C uptake[1].
UNSPSC
12352005
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pcsk9-in-27.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C=CC=C1Cl)C2=CN=C(N[C@@H]3C[C@@H](NC4=CN=C(C5CC5)C=N4)CC3)C=C2
Molecular Formula
C22H23ClN6O
Molecular Weight
422.91
References & Citations
[1]Gavin Donal O’MAHONY, et al. Pcsk9 inhibitors and methods of use thereof. Patent. WO2024062089A1
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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