Products for Research Use Only
RegisterLogin

PCSK9-IN-10

CAT: 0804-HY-152221-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-152221-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PCSK9-IN-10 is a potent and orally active PCSK9 inhibitor with an IC50 value of 6.4 µM. PCSK9-IN-10 increases the expression of LDLR protein and decreases the expression of PCSK9. PCSK9-IN-10 reduces atherosclerosis progression. PCSK9-IN-10 has the potential for the research of hyperlipidemia[1].
CAS Number
368434-98-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pcsk9-in-10.html
Purity
98.89
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N1C)N(C)C2=C(N(CC3=CC=CC(OC)=C3)C(NCCOC)=N2)C1=O
Molecular Formula
C18H23N5O4
Molecular Weight
373.41
Precautions
H302, H315, H319
References & Citations
[1]Qiao MQ, et al. Structure-activity relationship and biological evaluation of xanthine derivatives as PCSK9 inhibitors for the treatment of atherosclerosis. Eur J Med Chem. 2022 Dec 26;247:115047.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-155415PCSK9-IN-20
HY-N10702PCSK9-IN-9
HY-161435PCSK9-IN-27
HY-134482PCSK9-IN-1
HY-157434-01PCSK9-IN-23
HY-161940-01PCSK9-IN-30
HY-148758-01PCSK9-IN-13
HY-168156PCSK9-IN-32
HY-153453PCSK9-IN-17
HY-175189PCSK9-IN-33

Alternative Products

CatalogName
BA8064-10PCSK9-IN-10
pro-2043PCSK9
048564PCSK9 (Boehringer PCSK9) discontinued
048566PCSK9 (Schering patent PCSK9) discontinued
C00552-1mgAnti-PCSK9 (Boehringer anti-PCSK9)
048565PCSK9 (Merck patent PCSK9) discontinued

Popular Products