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PCSK9-IN-9

CAT: 0804-HY-N10702Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10702Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC50 value of 11.9 μM[1].
UNSPSC
12352005
Target
PCSK9
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pcsk9-in-9.html
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C/C=C\CCCCCCCC1=CC2=C(C(O)=CC(O)=C2)C(O1)=O
Molecular Formula
C26H36O4
Molecular Weight
412.56
References & Citations
[1]Pel P, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega, 2022.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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