PCSK9-IN-1

PCSK9-IN-1

• CAS Number: 2730022-10-1
• UNSPSC Description: PCSK9-IN-1 is a novel and highly potent cyclic peptide PCSK9 inhibitor with a Ki value of 1.46 nM.
• Target Antigen: PCSK9
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/pcsk9-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H](C)[C@@H](C(N[C@@H](CC1=CC=C(OC)C=C1)C(N2[C@@](C(NCCSC3)=O)(C)CCC2)=O)=O)NC([C@H]4NC([C@H](CC5=CNC6=C5C=C(F)C=C6)NC([C@H](CC7=CC(CNC(CC4)=O)=CC=C7)NC([C@@H](C)NC([C@H](C)NC(CCSCC8=CC=CC3=C8)=O)=O)=O)=O)=O)=O
• Molecular Weight: 1290.53
• References & Citations: [1]Alleyne C, et al. Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J Med Chem. 2020 Nov 25;63(22):13796-13824.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported