Anti-Integrin alpha V Antibody [SC56-07]

Anti-Integrin alpha V Antibody [SC56-07]

• Description: Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
• Product Name Alternative: CD51 antibody Integrin alpha-V light chain antibody integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody Integrin, alpha V antibody Integrin, beta 6 antibody ITAV_HUMAN antibody ITGAV antibody ITGB6 antibody Vitronectin receptor subunit alpha antibody
• Abbreviation: ITGAV, MSK8, VNRA, ITGB6
• CAS Number: 9007-83-4
• Swiss Prot: P06756 Human; P43406 Mouse
• Cellular Locus: Membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within of Human Integrin alpha V aa 1000-1048 / 1048.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, FC, IHC-P
• Positive Control: A549 cell lysate, HeLa cell lysate, NIH/3T3 cell lysate, C6 cell lysate, rat heart tissue lysate, A549, SiHa, MCF-7, human placenta tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:5,000 ;IF-Cell: 1:50-1:100 ;FC: 1:50-1:100 ;IHC-P: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 116 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: True