Integrin alpha 5 Recombinant Rabbit Monoclonal Antibody [JJ08-94]

Integrin alpha 5 Recombinant Rabbit Monoclonal Antibody [JJ08-94]

• Description: Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
• Product Name Alternative: CD49 antigen-like family member E antibody CD49e antibody Fibronectin receptor subunit alpha antibody Fibronectin receptor, alpha subunit antibody FNRA antibody Integrin alpha 5 (fibronectin receptor alpha) antibody Integrin alpha-5 antibody Integrin alpha-5 light chain antibody Integrin alpha-F antibody Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) antibody ITA5_HUMAN antibody Itga5 antibody Very late activation protein 5, alpha subunit antibody VLA-5 antibody VLA5 antibody VLA5A antibody
• Abbreviation: ITGA5
• CAS Number: 9000-83-3
• Swiss Prot: P08648 Human, P11688 Mouse
• Cellular Locus: Membrane, Cell junction, Cell surface.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Monkey, Rat
• Immunogen: Synthetic peptide within C-terminal human Integrin alpha 5.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
• Positive Control: HeLa cell lysate, A549 cell lysate, U-937 cell lysate, NIH/3T3 cell lysate, COS-1 cell lysate, Mouse liver tissue lysate, Rat liver tissue lysate, NIH/3T3, human kidney tissue, human placenta tissue, human tonsil tissue, mouse endometrium tissue, Hela, Jurkat.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:200-1:1,000 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 115 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes