IKK beta Rabbit Polyclonal Antibody

IKK beta Rabbit Polyclonal Antibody

• Description: The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase α (IKKα), previously designated CHUK, interacts with IkB-α and specifically phosphorylates Iκβ-α on Serine 32 and 36, the sites that trigger its degradation. IKKα appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKα is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.
• Product Name Alternative: I kappa B kinase 2 antibody I kappa B kinase beta antibody I-kappa-B kinase 2 antibody I-kappa-B-kinase beta antibody IkBKB antibody IKK beta antibody IKK-B antibody IKK-beta antibody IKK2 antibody IKKB antibody IKKB_HUMAN antibody IMD15 antibody Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta antibody Inhibitor of nuclear factor kappa-B kinase subunit beta antibody NFKBIKB antibody Nuclear factor NF-kappa-B inhibitor kinase beta antibody
• Abbreviation: I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, IKK2, NFKBIKB, IKKB
• CAS Number: 9007-83-4
• Swiss Prot: O14920 Human, O88351 Mouse, Q9QY78 Rat
• Cellular Locus: Nucleus. Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human IKK beta aa 501-649 / 756.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: HL-60 cell lysate, THP-1 cell lysate, Hela, HUVEC, rat testis tissue, human tonsil tissue, human breast carcinoma tissue, human placenta tissue, mouse testis tissue, A549.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 87 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No