IKK alpha Rabbit Polyclonal Antibody
CAT:
992-ER30911
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

IKK alpha Rabbit Polyclonal Antibody
- Description: Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation. Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer. Mutations in IKK-α in humans have been linked to lethal fetal malformations. The phenotype of these mutant fetuses is similar to the mouse IKK-α null phenotype, and is characterized by shiny, thickened skin and truncated limbs. Decreased IKK-α activity has been reported in a large percentage of human squamous cell carcinomas, and restoring IKK-α in mouse models of skin cancer has been shown to have an anti-tumorigenic effect.
- Product Name Alternative: chuk antibody CHUK1 antibody Conserved Helix Loop Helix Ubiquitous Kinase antibody Conserved helix loop ubiquitous kinase antibody Conserved helix-loop-helix ubiquitous kinase antibody I Kappa B Kinase 1 antibody I Kappa B Kinase Alpha antibody I-kappa-B kinase 1 antibody I-kappa-B kinase alpha antibody IkappaB kinase antibody IkB kinase alpha subunit antibody IkBKA antibody IKK 1 antibody IKK A antibody IKK a kinase antibody IKK-A antibody IKK-alpha antibody IKK1 antibody IKKA antibody IKKA_HUMAN antibody Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody NFKBIKA antibody Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody Nuclear factor NF kappa B inhibitor kinase alpha antibody Nuclear factor NF-kappa-B inhibitor kinase alpha antibody Nuclear factor NFkappaB inhibitor kinase alpha antibody Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody TCF-16 antibody TCF16 antibody Transcription factor 16 antibody
- Abbreviation: I-kappa-B kinase alpha,IKK-A,IKK-alpha,IkBKA,IkappaB kinase,IKK1,NFKBIKA,TCF-16
- CAS Number: 9007-83-4
- Swiss Prot: O15111 Human
- Cellular Locus: Cytoplasm, nucleus.
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Synthetic peptide within Human Ikk alpha aa 1-50 / 745.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IF-Cell, IHC-P, FC
- Positive Control: HeLa cell lysate, HCT 116 cell lysate, SK-OV-3 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, mouse kidney tissue lysate, rat kidney tissue lysate, N2A, human mammary gland tissue, human gastric carcinoma tissue.
- Concentration: 1 mg/mL
- Dilution: WB: 1:2,000 ;IF-Cell: 1:200 ;IHC-P: 1:200
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 85 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Recombinant Antibody: No