IKK alpha + IKK beta Recombinant Rabbit Monoclonal Antibody [SN63-02]

IKK alpha + IKK beta Recombinant Rabbit Monoclonal Antibody [SN63-02]

• Description: IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB. Activated IKK-β phosphorylates a protein called the inhibitor of NF-κB, IκB (IκBα), which binds NF-κB to inhibit its function. IKK-α and IKK-β phosphorylate the IκB proteins, marking them for degradation via ubiquitination and allowing NF-κB transcription factors to go into the nucleus. Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation.
• Product Name Alternative: CHUK antibody Conserved helix loop helix ubiquitous kinase antibody I kappa B kinase 1 antibody I kappa B kinase 2 antibody I Kappa B kinase alpha antibody I Kappa B kinase beta antibody IkB kinase alpha subunit antibody IkBKA antibody IkBKB antibody IKK a kinase antibody IKK alpha antibody IKK beta antibody IKK1 antibody IKK2 antibody IKKA antibody IKKB antibody IMD15 antibody Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta antibody Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody Inhibitor of nuclear factor kappa-B kinase subunit beta antibody NFKBIKA antibody NFKBIKB antibody Nuclear factor NF kappa B inhibitor kinase beta antibody Nuclear factor NFkappaB inhibitor kinase alpha antibody TCF 16 antibody TCF16 antibody Transcription factor 16 antibody
• Abbreviation: I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, IKK1, NFKBIKA, TCF-16, CHUK, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, IKK2, NFKBIKB, IKBKB
• CAS Number: 9000-83-3
• Swiss Prot: O14920 Human, O15111 Human, O88351 Mouse, Q60680 Mouse, Q9QY78 Rat
• Cellular Locus: Cytoplasm, Nucleus, Membrane raft.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human IKK beta aa 450-652 / 756.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IP
• Positive Control: HeLa cell lysate, 293T cell lysate, Daudi cell lysate, A431, NIH/3T3, C6.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IF-Cell: 1:100-1:500 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 87 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes