Histone H4 (acetyl K8) Recombinant Rabbit Monoclonal Antibody [PS01-25]

Histone H4 (acetyl K8) Recombinant Rabbit Monoclonal Antibody [PS01-25]

• Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H4K8ac is part of 17 modifications of a group of active promoters. H4K8ac is found more often in active promoters and transcribed regions than other marks. H4K8ac is modified by a different group of enzymes than other H4 lysines.
• Product Name Alternative: dJ160A22.1 antibody dJ160A22.2 antibody dJ221C16.1 antibody dJ221C16.9 antibody FO108 antibody H4 antibody H4.k antibody H4/a antibody H4/b antibody H4/c antibody H4/d antibody H4/e antibody H4/g antibody H4/h antibody H4/I antibody H4/j antibody H4/k antibody H4/m antibody H4/n antibody H4/p antibody H4_HUMAN antibody H4F2 antibody H4F2iii antibody H4F2iv antibody H4FA antibody H4FB antibody H4FC antibody H4FD antibody H4FE antibody H4FG antibody H4FH antibody H4FI antibody H4FJ antibody H4FK antibody H4FM antibody H4FN antibody H4M antibody HIST1H4A antibody HIST1H4B antibody HIST1H4C antibody HIST1H4D antibody HIST1H4E antibody HIST1H4F antibody HIST1H4H antibody HIST1H4I antibody HIST1H4J antibody HIST1H4K antibody HIST1H4L antibody HIST2H4 antibody HIST2H4A antibody Hist4h4 antibody Histone 1 H4a antibody Histone 1 H4b antibody Histone 1 H4c antibody Histone 1 H4d antibody Histone 1 H4e antibody Histone 1 H4f antibody Histone 1 H4h antibody Histone 1 H4i antibody Histone 1 H4j antibody Histone 1 H4k antibody Histone 1 H4l antibody Histone 2 H4a antibody histone 4 H4 antibody Histone H4 antibody MGC24116 antibody H4K8ac antibody
• Abbreviation: Histone H4 H4C1 H4/A, H4FA, HIST1H4A H4C2 H4/I, H4FI, HIST1H4B H4C3 H4/G, H4FG, HIST1H4C H4C4 H4/B, H4FB, HIST1H4D H4C5 H4/J, H4FJ, HIST1H4E H4K8ac
• CAS Number: 9000-83-3
• Swiss Prot: P62805 Human, P62806 Mouse, P62804 Rat
• Cellular Locus: Nucleus. Chromosome.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Histone H4 aa 1-20 (acetyl K8).
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, ChIP
• Positive Control: Human skin tissue, rat skin tissue, human colon carcinoma tissue, PC-12, Hela cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:50 ;IHC-P 1:1,000-1:5,000 ;ChIP: Use 0.5~2 μg for 25 μg of chromatin.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 11 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes