TAB1 Rabbit Polyclonal Antibody

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta, interleukin-1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. TAB1 contains multiple amino acid sites that are phosphorylated and ubiquitinated. This protein plays an important role in skin homeostasis, wound repair, and oncogenesis.

9007-83-4

2310012M03Rik antibody 3'-Tab1 antibody MAP3K7IP 1 antibody MAP3K7IP1 antibody MGC57664 antibody Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody TAB 1 antibody TAB1 antibody TAB1_HUMAN antibody TAK1 binding protein 1 antibody TAK1-binding protein 1 antibody TGF beta activated kinase 1 binding protein 1 antibody TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody TGF-beta-activated kinase 1-binding protein 1 antibody Transforming growth factor beta activated kinase binding protein 1 antibody

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 TGF-beta-activated kinase 1-binding protein 1 TAK1-binding protein 1 TAB1 MAP3K7IP1

Q15750 Human, Q8CF89 Mouse

Cytosol.

Recombinant protein within human TAB1 aa 1-250.

Non-conjugated

Rabbit polyclonal Antibody

WB, IHC-P

293T cell lysate, NIH/3T3 cell lysate, mouse brain tissue lysates, rat large intestine tissue, human lung carcinoma tissue, human testis tissue.

1.99 mg/mL

WB: 1:1,000 ;IHC-P: 1:800

Immunogen affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 55 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.