CD3E Rabbit Polyclonal Antibody

CAT: 0992-HA500344Size: 100 µLDry Ice: NoHazardous: No
CAT#:0992-HA500344Size:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
The CD3 protein is a T-cell marker, a complex of four structurally distinct membrane glycoprotein isoforms, 20-50 kDa, comprising extracellular, transmembrane and intracellular domains. The CD3 complex is responsible for mediating signal transduction to the internal environment upon antigenic recognition by TCR, causing T-cell proliferation and release of cytokines. Except for a weak expression in Purkinje cells (with some of the Abs) and activated NK-cells, CD3 is found only in T-cells. CD3 appear in the cytoplasm of prothymocytes, and on the surface of about 95% of thymocytes, while cytoplasmic CD3 is lost as the cells differentiate into medullary thymocytes. In therapy resistant celiac disease, a shift from membranous to cytoplasmic CD3 expression is seen (together with loss of CD8). In malignant lymphomas, CD3 is a pan-T-cell lineage-restricted antigen, detected in 80-97% of the T-cell lymphomas. Mature T-cell lymphomas including cases of mycosis fungoides, peripheral T-cell lymphoma and anaplastic large cell lymphoma may aberrantly lose CD3. NK-cell lymphomas can show a cytoplasmic reaction. Reed-Sternberg cells may show a globular paranuclear reaction. CD3 is an important marker in the classification of malignant lymphomas and lymphoid leukaemias. Also the marker is useful for the identification of T-cells in, e.g., celiac disease, lymphocytic colitis and colorectal carcinomas associated with loss of a mismatch repair protein.
CAS Number
9007-83-4
Product Name Alternative
CD3 epsilon antibody CD3e antibody CD3e antigen antibody CD3e antigen epsilon polypeptide (TiT3 complex) antibody CD3E antigen epsilon polypeptide antibody CD3E antigen, epsilon subunit antibody CD3e molecule epsilon antibody CD3e molecule, epsilon (CD3 TCR complex) antibody CD3e molecule, epsilon (CD3-TCR complex) antibody CD3E_HUMAN antibody IMD18 antibody T cell antigen receptor complex epsilon subunit of T3 antibody T cell surface antigen T3/Leu 4 epsilon chain antibody T cell surface glycoprotein CD3 epsilon chain antibody T-cell surface antigen T3/Leu-4 epsilon chain antibody T-cell surface glycoprotein CD3 epsilon chain antibody T3E antibody TCRE antibody
Abbreviation
CD3E
Swiss Prot
P07766 Human, P22646 Mouse,
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human CD3E aa 158-207 / 207.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
Jurkat cell lysate, mouse thymus tissue lysate, rat thymus tissue lysate.
Concentration
1 mg/mL
Dilution
WB: 1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 23 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

Related Products

CatalogName
ER1901-82CD35 Rabbit Polyclonal Antibody
ER31219CD31 Rabbit Polyclonal Antibody
ER2001-14CD35 Rabbit Polyclonal Antibody
ER1802-7CD36 Rabbit Polyclonal Antibody
0108-2CD34 Rabbit Polyclonal Antibody
ER1706-66CD34 Rabbit Polyclonal Antibody
ER0802CD34 Rabbit Polyclonal Antibody
ER80501CD3 epsilon Rabbit Polyclonal Antibody
0805-7CD3 zeta Rabbit Polyclonal Antibody
HA500238BTNL3 Rabbit Polyclonal Antibody

Alternative Products

CatalogName
TA383934CD3E Rabbit Polyclonal Antibody
TA321191Anti-CD3E Rabbit Polyclonal Antibody
MBS8567293-01CD3E Polyclonal Antibody
11-7546-100Polyclonal Antibody to CD3e

Popular Products