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GCSF Receptor Rabbit Polyclonal Antibody

CAT: 0992-HA500282Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500282Size:100 µL
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Description
Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. Mutations in CSF3R acquired in multipotent hematopoietic progenitor cells and resulting in truncated hyper-responsive forms of the receptor, have been identified in most cases of severe congenital neutropenia (SCN). Patients carrying these mutations are at risk for developing myelodysplastic syndromes and/or acute myeloid leukemia. Constitutive mutations leading to hyporesponsive forms of the receptor are responsible for the refractoriness to CSF3 treatment observed in some SCN patients.
CAS Number
9007-83-4
Product Name Alternative
CD 114 antibody CD114 antibody CD114 antigen antibody Colony stimulating factor 3 receptor (granulocyte) antibody Colony stimulating factor 3 receptor antibody CSF 3R antibody CSF3R antibody CSF3R_HUMAN antibody Csfgr antibody G CSF R antibody G-CSF receptor antibody G-CSF-R antibody GCSFR antibody Granulocyte colony stimulating factor receptor antibody Granulocyte colony-stimulating factor receptor antibody OTTHUMP00000009703 antibody OTTHUMP00000009704 antibody OTTHUMP00000009705 antibody
Abbreviation
CSF3R
Swiss Prot
Q99062 Human
Cellular Locus
Secreted, Cell membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human GCSF Receptor aa 787-836.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
HL-60 cell lysate, THP-1 cell lysate, SH-SY5Y cell lysate, Hela, THP-1.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;FC: 1:500-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 92 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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