GCSF Receptor Rabbit Polyclonal Antibody

GCSF Receptor Rabbit Polyclonal Antibody

• Description: Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. Mutations in CSF3R acquired in multipotent hematopoietic progenitor cells and resulting in truncated hyper-responsive forms of the receptor, have been identified in most cases of severe congenital neutropenia (SCN). Patients carrying these mutations are at risk for developing myelodysplastic syndromes and/or acute myeloid leukemia. Constitutive mutations leading to hyporesponsive forms of the receptor are responsible for the refractoriness to CSF3 treatment observed in some SCN patients.
• Product Name Alternative: CD 114 antibody CD114 antibody CD114 antigen antibody Colony stimulating factor 3 receptor (granulocyte) antibody Colony stimulating factor 3 receptor antibody CSF 3R antibody CSF3R antibody CSF3R_HUMAN antibody Csfgr antibody G CSF R antibody G-CSF receptor antibody G-CSF-R antibody GCSFR antibody Granulocyte colony stimulating factor receptor antibody Granulocyte colony-stimulating factor receptor antibody OTTHUMP00000009703 antibody OTTHUMP00000009704 antibody OTTHUMP00000009705 antibody
• Abbreviation: CSF3R
• CAS Number: 9007-83-4
• Swiss Prot: Q99062 Human
• Cellular Locus: Secreted, Cell membrane.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within human GCSF Receptor aa 787-836.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, FC
• Positive Control: HL-60 cell lysate, THP-1 cell lysate, SH-SY5Y cell lysate, Hela, THP-1.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;FC: 1:500-1:1,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 92 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No