Vitamin D Receptor Rabbit Polyclonal Antibody

Vitamin D Receptor Rabbit Polyclonal Antibody

• Description: The active metabolite of vitamin D modulates the expression of a wide variety of genes in a developmentally specific manner. This secosteroid hormone can up- or downregulate the expression of genes involved in a diverse array of responses such as proliferation, differentiation and calcium homeostasis. 1,25- (OH)2-vitamin D3 exerts its effects through interaction with the vitamin D receptor (VDR), a member of the superfamily of hormone-activated nuclear receptors. In its ligand-bound state, the VDR forms heterodimers with the 9-cis retinoic acid receptor, RXR, and affects gene expression by binding specific DNA sequences known as hormone response elements, or HREs. In addition to regulating the above-mentioned cellular responses, 1,25- (OH)2-vitamin D3 exhibits antiproliferative properties in osteosarcoma, melanoma, colon carcinoma and breast carcinoma cells.
• Product Name Alternative: 1 25 dihydroxyvitamin D3 receptor antibody 1 antibody 1,25 dihydroxyvitamin D3 receptor antibody 1,25-@dihydroxyvitamin D3 receptor antibody 25-dihydroxyvitamin D3 receptor antibody Member 1 antibody NR1I1 antibody Nuclear receptor subfamily 1 group I member 1 antibody PPP1R163 antibody Protein phosphatase 1, regulatory subunit 163 antibody VDR antibody VDR_HUMAN antibody Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody Vitamin D hormone receptor antibody Vitamin D nuclear receptor variant 1 antibody Vitamin D receptor antibody Vitamin D3 receptor antibody
• Abbreviation: VDR, NR1I1
• CAS Number: 9007-83-4
• Swiss Prot: P11473 Human
• Cellular Locus: Nucleus. Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human Vitamin D Receptor aa 371-420 / 427.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, FC
• Positive Control: PC-3M, Human small intestine tissue lysate, LOVO.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000 ;FC: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 48 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No