Progesterone receptor Rabbit Polyclonal Antibody

Progesterone receptor Rabbit Polyclonal Antibody

• Description: The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen-inducible promoters within a single copy of the PR gene. The first 164 amino acids of PR-B are absent in PR-A. Progesterone-bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms. Interestingly, the ID is functionally active only in PR-A and is necessary for steroid hormone transrepression by PR-A, suggesting that PR-A and PR-B may have different conformations in the cell.
• Product Name Alternative: NR3C3 antibody Nuclear receptor subfamily 3 group C member 3 antibody PGR antibody PR antibody PRA antibody PRB antibody PRGR_HUMAN antibody Progesterone receptor antibody Progestin receptor form A antibody Progestin receptor form B antibody
• Abbreviation: Progesterone receptor,pr,Nuclear receptor subfamily 3 group C member 3,PGR
• CAS Number: 9007-83-4
• Swiss Prot: P06401 Human
• Cellular Locus: Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within Human Progesterone receptor aa 30-250.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, FC
• Positive Control: AN3CA cell lysates, A549 cell, MCF-7 cell.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2000;IF-Cell: 1:100-1:500;FC: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size 99 kDa.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No