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Gemin 2 Rabbit Polyclonal Antibody

CAT: 0992-HA500106Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500106Size:100 µL
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Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
CAS Number
9007-83-4
Product Name Alternative
Component of gems 2 antibody Gem (nuclear organelle) associated protein 2 antibody Gem associated protein 2 antibody GEMI2_HUMAN antibody Gemin-2 antibody gemin2 antibody SIP 1 antibody SIP-1 antibody SIP1 antibody SIP1 delta antibody SIP1-delta antibody SMN interacting protein 1 antibody SMN interacting protein 1 delta antibody SMN-interacting protein 1 antibody Survival interacting protein 1 antibody Survival of motor neuron protein interacting protein 1 antibody Survival of motor neuron protein-interacting protein 1 antibody
Abbreviation
Gem-associated protein 2 Gemin-2 Component of gems 2 Survival of motor neuron protein-interacting protein 1 SMN-interacting protein 1
Swiss Prot
O14893 Human
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human Gemin 2 aa 10-60.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
293 cell lysate, MCF-7 cell lysate, K562 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 32 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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