Pygopus 2 Rabbit Polyclonal Antibody

Pygopus 2 Rabbit Polyclonal Antibody

• Description: Pygopus 2, also known as PYGO2, is a 406 amino acid protein that is the human homolog of the Drosophila pygopus protein. Localized to the nucleus, Pygopus 2 contains one PHD finger that interacts with the homology domain of the Wnt signaling protein Bcl-9. This interaction joins Pygopus 2 with the ∫-catenin/TCF complex (a crucial complex in Wnt signaling), thereby allowing ∫-catenin to transcriptionally activate Wnt target genes. Association of Pygopus 2 with proteins involved in the Wnt signaling pathway is thought to regulate proper signal transduction, as absence of the Pygopus 2/∫-catenin interaction may play a role in development of B-cell malignancies. In addition, Pygopus 2 expression is upregulated in and required for the growth of breast cancer cells, suggesting a crucial role in carcinogenesis.
• Product Name Alternative: 1190004M21Rik antibody FLJ33226 antibody PP7910 antibody PYGO2 antibody Pygo2 protein antibody PYGO2_HUMAN antibody Pygopus 2 antibody pygopus homolog 2 (Drosophila) antibody Pygopus homolog 2 antibody
• Abbreviation: PYGO2
• CAS Number: 9007-83-4
• Swiss Prot: Q9BRQ0 Human
• Cellular Locus: Nucleus
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide within Human Pygopus aa 31-80 / 406.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, FC
• Positive Control: Hela, NCCIT.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000;FC: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 41kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No