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Pygopus 2 Rabbit Polyclonal Antibody

CAT: 0992-R1510-27Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1510-27Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pygopus 2, also known as PYGO2, is a 406 amino acid protein that is the human homolog of the Drosophila pygopus protein. Localized to the nucleus, Pygopus 2 contains one PHD finger that interacts with the homology domain of the Wnt signaling protein Bcl-9. This interaction joins Pygopus 2 with the ∫-catenin/TCF complex (a crucial complex in Wnt signaling), thereby allowing ∫-catenin to transcriptionally activate Wnt target genes. Association of Pygopus 2 with proteins involved in the Wnt signaling pathway is thought to regulate proper signal transduction, as absence of the Pygopus 2/∫-catenin interaction may play a role in development of B-cell malignancies. In addition, Pygopus 2 expression is upregulated in and required for the growth of breast cancer cells, suggesting a crucial role in carcinogenesis.
CAS Number
9007-83-4
Product Name Alternative
1190004M21Rik antibody FLJ33226 antibody PP7910 antibody PYGO2 antibody Pygo2 protein antibody PYGO2_HUMAN antibody Pygopus 2 antibody pygopus homolog 2 (Drosophila) antibody Pygopus homolog 2 antibody
Abbreviation
PYGO2
Swiss Prot
Q9BRQ0 Human
Cellular Locus
Nucleus
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within Human Pygopus aa 31-80 / 406.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, FC
Positive Control
Hela, NCCIT.
Concentration
1 mg/mL
Dilution
WB: 1:1,000;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
41kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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Alternative Products

CatalogName
NBP2-20019Rabbit Polyclonal Pygopus-2 Antibody
NBP1-42665Rabbit Polyclonal Pygopus-1 Antibody
GTR17710129-01Pygopus 2 Rabbit Polyclonal Antibody
NBP1-46172HRabbit Polyclonal Pygopus-2 Antibody [HRP]
NBP1-42665FRabbit Polyclonal Pygopus-1 Antibody [FITC]
NBP1-46172APCRabbit Polyclonal Pygopus-2 Antibody [Allophycocyanin]
TA339157Pygopus 2 (PYGO2) Rabbit Polyclonal Antibody
NBP1-46172PERabbit Polyclonal Pygopus-2 Antibody [PE]
GTR18466638Pygopus 2 Rabbit Polyclonal Antibody (BF350)
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