Mitofusin 2 Rabbit Polyclonal Antibody

Mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are homologs for the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins and are mediators of mitochondrial fusion. A GTPase domain is required for Mfn protein function but the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. They are essential for embryonic development and may play a role in the pathobiology of obesity. Although the Mfn1 and Mfn2 genes are broadly expressed, they show different levels of expression in different tissues. Two Mfn1 transcripts are elevated in heart, while Mfn2 mRNA is abundantly expressed in heart and muscle tissue but present only at low levels in many other tissues. Mfn1 localizes to mitochondria and participates in at least two different high molecular weight protein complexes in a GTP-dependent manner. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2.

9007-83-4

CMT2A antibody CMT2A2 antibody CPRP 1 antibody CPRP1 antibody EC 3.6.5.- antibody Fzo antibody HSG antibody hyperplasia suppressor gene antibody Hypertension related protein 1 antibody KIAA0214 antibody MARF antibody MFN 2 antibody Mfn2 antibody MFN2_HUMAN antibody Mitochondrial assembly regulatory factor antibody Mitofusin-2 antibody Mitofusin2 antibody Transmembrane GTPase MFN2 antibody

MFN2, CPRP1, KIAA0214

O95140 Human, Q8R500 Rat

Mitochondrion.

Recombinant protein within human Mitofusin 2 aa 378-602.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell, FC

Rat heart tissue lysates, A431, LOVO, PC-3M, Jurkat.

1 mg/mL

WB: 1:500-1:1,000;IF-Cell: 1:50-1:200;FC: 1:50-1:100

Immunogen affinity purified.

Liquid

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

86 kDa

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.