GPR161 Rabbit Polyclonal Antibody
CAT:
992-HA500098
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
GPR161 Rabbit Polyclonal Antibody
- Description: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
- Product Name Alternative: G protein coupled receptor 161 antibody G protein coupled receptor RE2 antibody RE2 antibody Gm208 G-protein coupled receptor 161
- Abbreviation: GPR161
- CAS Number: 9007-83-4
- Swiss Prot: B2RPY5 Mouse
- Cellular Locus: Cilium membrane, Cell membrane.
- Host: Rabbit
- Species Reactivity: Mouse, Rat
- Immunogen: Recombinant protein within mouse GPR161 aa 323-545.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IHC-P
- Positive Control: Mouse cerebellum tissue lysate, rat colon tissue lysate, rat uterus tissue, mouse kidney tissue.
- Concentration: 1 mg/mL
- Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: 60 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
- Recombinant Antibody: No