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GPR132 Rabbit Polyclonal Antibody

CAT: 0992-R1308-8Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1308-8Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G protein coupled receptor 132, also termed G2A, is classified as a member of the proton sensing G protein coupled receptor (GPR) subfamily. Like other members of this subfamily, i.e. GPR4, OGR1 (GPR68), and TDAG8 (GPR65), G2A is a G protein coupled receptor that resides in the cell surface membrane, senses changes in extracellular pH, and can alter cellular function as a consequence of these changes. Subsequently, G2A was suggested to be a receptor for lysophosphatidylcholine (LPC). However, the roles of G2A as a pH-sensor or LPC receptor are disputed. Rather, current studies suggest that it is a receptor for certain metabolites of the polyunsaturated fatty acid, linoleic acid. G2A was initially defined as one of the gene products whose production was stimulated in mouse pre-B lymphocytes (see Immunoglobulin heavy chain) by transfecting the cells with the human oncogene (i.e., cancer causing) BCR-ABL or by treating the cells with DNA damaging agents; its expression in these cells blocked their progression through the cell cycle specifically at the G2-M DNA damage checkpoint. A report working with human neutrophils proposed that G2A was a receptor for a phospholipid, lysophosphatidylcholine (LPC), and a Sphingomyelin, sphingosylphosphorylcholine.
CAS Number
9007-83-4
Product Name Alternative
G Protein Coupled Receptor G2A antibody G2 accumulation protein antibody G2A antibody GP132_HUMAN antibody GPR132 antibody Probable G-protein coupled receptor 132 antibody
Abbreviation
GPR132
Swiss Prot
Q9UNW8 Human, Q9Z282 Mouse
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human GPR132 aa 1-50 / 380.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell
Positive Control
HeLa cell lysate, 293T cell lysate, Human brain tissue lysate, Mouse skeletal muscle tissue lysate, Rat skeletal muscle tissue lysate, A172.
Concentration
1 mg/mL
Dilution
WB: 1:2,000-1:5,000 ;IF-Cell: 1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 42 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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