Integrin beta 3 Recombinant Rabbit Monoclonal Antibody [JE22-64]

Integrin beta 3 Recombinant Rabbit Monoclonal Antibody [JE22-64]

• Description: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition.
• Product Name Alternative: BDPLT16 antibody BDPLT2 antibody CD 61 antibody CD61 antibody CD61 antigen antibody GP3A antibody GPIIIa antibody GT antibody HPA 1 antibody HPA 4 antibody Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody Integrin beta chain beta 3 antibody Integrin beta-3 antibody ITB3_HUMAN antibody ITG B3 antibody ITGB 3 antibody ITGB3 antibody NAIT antibody platelet fibrinogen receptor antibody Platelet fibrinogen receptor beta subunit antibody Platelet fibrinogen receptor, beta subunit antibody Platelet glycoprotein IIIa antibody Platelet glycoprotein IIIa precursor antibody Platelet membrane glycoprotein IIIa antibody PTP antibody
• Abbreviation: ITGB3
• CAS Number: 9000-83-3
• Swiss Prot: P05106 Human, O54890 Mouse
• Cellular Locus: Cell membrane, lamellipodium membrane, postsynaptic cell membrane, focal adhesion, synapse.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide within Human Integrin beta 3 aa 739-788 / 788.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: HUVEC cell lysates, human thyroid tissue, human colon carcinoma tissue, human spleen tissue.
• Concentration: 1 mg/mL
• Dilution: WB:1:500-1:2,000 ;IHC-P:1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 87 kDa (Predicted band size)
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes