Integrin beta 4 Recombinant Rabbit Monoclonal Antibody [JM11-06]

Integrin beta 4 Recombinant Rabbit Monoclonal Antibody [JM11-06]

• Description: Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Integrin β4 (ITGB4), also known as CD104, is a 1,822 amino acid single-pass type I membrane protein belonging to the Integrin β chain family. Known to associate with Integrin α6, Integrin β4 functions as a receptor for Laminin and is predominantly expressed by epithelia. Integrin β4 exists as five alternatively spliced isoforms that are encoded by a gene located on human chromosome 17q25.1.
• Product Name Alternative: CD 104 antibody CD104 antibody CD104 antigen antibody gp150 antibody Integrin beta 4 subunit antibody Integrin beta-4 antibody ITB4_HUMAN antibody ITG B4 antibody ITGB 4 antibody Itgb4 antibody
• Abbreviation: ITGB4
• CAS Number: 9000-83-3
• Swiss Prot: P16144 Human, A2A863 Mouse
• Cellular Locus: Membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant protein within mouse Integrin beta 4 aa 1564-1822 / 1822 .
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: A431 cell lysate, A549 cell lysate, human breast carcinoma tissue, human tonsil tissue, human pancreas tissue, mouse colon tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 202 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes