Integrin beta 3 Rabbit Polyclonal Antibody

Integrin beta 3 Rabbit Polyclonal Antibody

• Description: Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
• Product Name Alternative: Antigen identified by monoclonal antibody L230 antibody CD 51 antibody CD 61 antibody CD51 antibody CD51 antigen antibody CD61 antibody CD61 antigen antibody DKFZp686A08142 antibody GP3A antibody GPIIIa antibody Integrin alpha V antibody Integrin alpha V vitronectin receptor alpha polypeptide antibody Integrin alpha V vitronectin receptor alpha polypeptide antigen CD51 antibody integrin alpha-V antibody Integrin alpha-V light chain antibody Integrin beta 3 antibody Integrin beta 3 platelet glycoprotein IIIa antigen CD61 antibody Integrin beta chain beta 3 antibody integrinVbeta3 antibody ITAV_HUMAN antibody ITGAV antibody ITGB 3 antibody ITGB3 antibody MSK 8 antibody MSK8 antibody Platelet glycoprotein IIIa antibody Platelet glycoprotein IIIa precursor antibody Platelet membrane glycoprotein IIIa antibody Vitronectin receptor alpha polypeptide antibody vitronectin receptor antibody Vitronectin receptor subunit alpha antibody VNR 1 antibody VNR1 antibody VNRA antibody
• Abbreviation: GPIIIa, ITGB3, GP3A
• CAS Number: 9007-83-4
• Swiss Prot: P05106 Human, O54890 Mouse
• Cellular Locus: Membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Integrin beta-3 aa 481-530 / 788.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P
• Positive Control: A431, rat spleen tissue lysate, rat ossature tissue, human tonsil tissue, human kidney tissue, human placenta tissue, mouse kidney tissue, HUVEC.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 87/110 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No