Sarcomeric Alpha Actinin Recombinant Rabbit Monoclonal Antibody [JE45-22]

Sarcomeric Alpha Actinin Recombinant Rabbit Monoclonal Antibody [JE45-22]

• Description: Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal and cardiac muscles and functions to anchor myofibrillar actin thin filaments and titin to Z-discs. The primary function of alpha-actinin-2 is to crosslink filamentous actin molecules and titin molecules from adjoining sarcomeres at Z-discs, a function that is modulated by phospholipids. It is clear from studies by Hampton et al. that this crosslinking can assume a variety of conformations, with preferences for 60° and 120° angles. Alpha-actinin-2 also functions in docking signalling molecules at Z-discs, and additional studies have also implicated alpha-actinin-2 in the binding of cardiac ion channels, Kv1.5 in particular.
• Product Name Alternative: Actin binding protein antibody Actinin alpha 2 antibody ACTN 2 antibody ACTN2 antibody ACTN2_HUMAN antibody Alpha actinin 2 antibody Alpha actinin skeletal muscle antibody Alpha actinin skeletal muscle isoform 2 antibody Alpha-actinin skeletal muscle isoform 2 antibody Alpha-actinin-2 antibody CMD1AA antibody F actin cross linking protein antibody F-actin cross-linking protein antibody
• Abbreviation: ACTN2
• CAS Number: 9000-83-3
• Swiss Prot: P35609 Human, Q9JI91 Mouse,
• Cellular Locus: Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human Sarcomeric Alpha Actinin aa 1-150.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IP, IHC-P
• Positive Control: Mouse skeletal muscle tissue lysate, mouse heart tissue lysate, rat heart tissue lysate, rat heart tissue, human colon tissue, human fetal skeletal muscle tissue, mouse heart tissue, mouse smooth muscle tissue.
• Concentration: 1 mg/mL
• Dilution: WB:1:500 ;IP:1:10-1:50 ;IHC-P:1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 104 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes