alpha Actinin Recombinant Mouse Monoclonal Antibody [A1G2-R]

alpha Actinin Recombinant Mouse Monoclonal Antibody [A1G2-R]

• Description: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
• Product Name Alternative: actinin 1 smooth muscle antibody Actinin alpha 1 antibody actinin, alpha 1 antibody ACTN 1 antibody Actn1 antibody ACTN1_HUMAN antibody Alpha Actinin 1 antibody Alpha actinin cytoskeletal isoform antibody Alpha-actinin cytoskeletal isoform antibody Alpha-actinin-1 antibody BDPLT15 antibody F actin cross linking protein antibody F-actin cross-linking protein antibody FLJ40884 antibody FLJ54432 antibody Non muscle alpha actinin 1 antibody Non-muscle alpha-actinin-1 antibody
• Abbreviation: ACTN1
• CAS Number: 9000-83-3
• Swiss Prot: P12814 Human, Q7TPR4 Mouse, Q9Z1P2 Rat
• Cellular Locus: Cell membrane, cytoskeleton, Z line, cell junction, ruffle.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human ACTN1 aa 388-619 / 892.
• Isotype: IgG1
• Clone: A1G2-R
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: HeLa cell lysate, A431 cell lysate, A549 cell lysate, HepG2 cell lysate, MCF7 cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, C6 cell lysate, human breast tissue, human breast carcinoma tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:5,000 ;IHC-P: 1:6,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 103 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes