Alpha Actinin 2 Recombinant Rabbit Monoclonal Antibody [JF0980]

Alpha Actinin 2 Recombinant Rabbit Monoclonal Antibody [JF0980]

• Description: The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
• Product Name Alternative: Actin binding protein antibody Actinin alpha 2 antibody ACTN 2 antibody ACTN2 antibody ACTN2_HUMAN antibody Alpha actinin 2 antibody Alpha actinin skeletal muscle antibody Alpha actinin skeletal muscle isoform 2 antibody Alpha-actinin skeletal muscle isoform 2 antibody Alpha-actinin-2 antibody CMD1AA antibody F actin cross linking protein antibody F-actin cross-linking protein antibody
• Abbreviation: ACTN2
• CAS Number: 9000-83-3
• Swiss Prot: P35609 Human, Q9JI91 Mouse,
• Cellular Locus: Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within human Alpha Actinin 2 aa 1-50/894.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IP
• Positive Control: Human heart tissue lysates, rat skeletal muscle tissue, rat heart tissue, mouse skeletal muscle tissue, mouse heart tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 104 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes